First post here, thanks in advance.

Intermittently, after my computer sleeps, upon wake up the mouse will not respond. I can still move the cursor with the k/b but no mouse.

On edit, I am using a few year old logitec optical wireless mouse and Vista H/P (32 bit)

Have you tried to find the latest drivers? Try here for downloads....
http://www.logitech.com/index.cfm/su...ads/downloads/ as you say it's a few years old new drivers could be the solution.

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AMD X2 BLACK EDITION 3.2GHz SAMURAI COOLER::GA-MA790X-DS4::3GB XMS2 PC6400 RAM:: POWERCOLOR 4870 512MB::160GB BARRACUDA RAID 0::SOUNDBLASTER AUDIGY::SAMSUNG WRITEMASTER DVD-RW/PIONEER DVD::HIPER MODULAR 530W PSU::THERMALTAKE ARMOUR Jr CASE::RAZER COPPERHEAD MOUSE::VISTA HOME PREMIUM SP1

I tried that first, however my model of mouse (cordless optical) is supposed to use native windows (Vista) drivers.

As I said in the original post, it is intermittent. It has not done it since I posted, but not having done anything yet I am sure its only time before it does it again.

Thank you

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Gigabyte GA-P35C-DS3R, E6750, Vista home prem(32) 2gig crucial ballistic,RAID Stripe.

You should try installing the MouseWare software for Windows Vista from Logitech. Its on the page that kemical referenced. Have you tried it? Since Logitech made your mouse they have probably updated their software and fixed bugs since Vista was released.