One I stumbled across, which covers almost everything, was Advanced Windowscare. I keep an image so dived into the deep end with the defaults set. It has a general cleaning option and a registry cleaning option. Does a really fantastic job. On their own recommendation, I then run Ccleaner, which seems to find a couple of deeper settings. No adware now or anything else. temp files all gone etc.
AVG Free as my antivirus and I am squeaky clean.