I Have An Acer 3000 With Pretty Much The Same Problem. The Mouse And Keyboard Works Fine In Post Windows Screens But Not In Windows. Then Somtimes It Works. Works Well With Usb M/k Also. I Notice That When It Does Not Work Its Over Working Itself As Seen In Task Manager Between 65-100% And When It Works 4-44%max.
Intrestingly Others With The Same Model Have The Same Or Similar Problem. I Jus Dont Know Why It Would Work In Safe Mode But Not Windows. I'll Post Results When I Switch Processers. God I Hate Amd's.