Hi

Yes most games work in Vista without any problem. However in the event that you find a game that does not run in vista you can try running the application in Compatibility Mode. To do so:

1. Open Windows Explorer.
2. Location the application executable.
3. Right click the executable and click the Properties option.
4. Select the Compatibility tab.
5. Select the Run This Program in Compatibility Mode option.
6. From the drop-down list, choose the operating system you ran before upgrading to Vista.
7. If necessary, select the option to run the program as an administration.
8. Click OK.

You can find a list of all games that run in vista at the link below:

Windows Vista RTM Software Compatibility List - IeXwiki