I have Trend Micro Internet Security that came with my new laptop and found it ok, but I uninstalled it and started using Eset Smart Security. I've always liked Eset's Nod32. It was the only virus scanner I could stand because it has a small footprint and the new Smart Security seems pretty good too.

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Dell XPS | M1730 Bone White
AGEIA PhysX M100
Intel Core 2 Duo T7500 @ 2.20GHz 4MB Cache
4GB DDR2 PC2-6400 RAM
1 TB Total HDD Space
Dual NVIDIA GeForce 8700M GT (SLI)
XPS | M1730 Dell Truelife HD Display
Creative Audigy HD
Logitech Z5500
XPS | M1730 Keyboard w/ Logitech Gaming LCD
Logitech G9 Gaming Mouse
EverGlide Gaming Surface
Windows Vista™ Home Premium