System specs please.. Oh just for starters, ( in case you haven't done this) make sure all drivers are up to date and Vista compatible. You can also right-click on the 'exe' and under compatibility click 'run as XP with SP2'.

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AMD X2 BLACK EDITION 3.2GHz SAMURAI COOLER::GA-MA790X-DS4 MOBO WITH NOCTUA NC-U6 HEATPIPE COOLING::3GB XMS2 PC6400 RAM:: POWERCOLOR 4870 512MB GDDR5 RAM::160GB BARRACUDA RAID 0::SOUNDBLASTER AUDIGY::SAMSUNG WRITEMASTER DVD-RW/PIONEER DVD::HIPER MODULAR 530W PSU::THERMALTAKE ARMOUR Jr CASE::RAZER COPPERHEAD MOUSE::VISTA HOME PREMIUM SP1