Well, I got some of it to work. I am not sure what did it but I think it was the Advanced Installer (free version) that did it (see: Free Windows Installer - MSI Installer Tool )

I downloaded the drivers, unzipped them, and then opened the Advanced Installer program. I made one installer file with the Advanced Installer for each .exe file. Then I installed them. When I plug the Mackie Spike in to the USB not everything works but at least the microphone input and the headphone outputs work and the monitor outputs work. I don't know about the other inputs and outputs but hopefully the work. The Mix doesn't work. The XD2 interface GUI won't install and so doesn't work. Turning the knobs on the Spike doesn't change the volume level on the Vista either.

Though this isn't the full package of features that worked on my Windows XP laptop, at least it is still possible to record and play back audio.

Thanks to those who made this possible.